Structural Basis for Substrate Specificity of Mammalian Neuraminidases
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چکیده
منابع مشابه
Structural Basis for Substrate Specificity of Mammalian Neuraminidases
The removal of sialic acid (Sia) residues from glycoconjugates in vertebrates is mediated by a family of neuraminidases (sialidases) consisting of Neu1, Neu2, Neu3 and Neu4 enzymes. The enzymes play distinct physiological roles, but their ability to discriminate between the types of linkages connecting Sia and adjacent residues and between the identity and arrangement of the underlying sugars h...
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FIG. 1. Effect of incr-easing substrate concentrations upon the magnitude of reaction with three influenza virus enzymes. Substrate in 0.5 si phosphate-buffered saline (PBS), pH 6 as indicated, and PBS to a total of 0.25 ml (human ac-GP, 4 mg/ ml; ovo, 40 mg/nil; PSM, 30 mg/ml), 0.05 ml of enzyme. Enzymes for these studies were virus concentrates prepared from infected chorioallantoic fluid by ...
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ژورنال
عنوان ژورنال: PLoS ONE
سال: 2014
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0106320